PlantImRecepV1, Main, Exploration, bibRecord, 000111

Molecular action mechanism of anti-inflammatory hydrolysates obtained from brewers' spent grain.

Identifieur interne : 000111 ( Main/Exploration ); précédent : 000110; suivant : 000112

Molecular action mechanism of anti-inflammatory hydrolysates obtained from brewers' spent grain.

Auteurs : Raúl E. Cian [Argentine] ; Cristina Hernández-Chirlaque [Espagne] ; Reyes Gámez-Belmonte [Espagne] ; Silvina R. Drago [Argentine] ; Fermín Sánchez De Medina [Espagne] ; Olga Martínez-Augustin [Espagne]

Source :

Journal of the science of food and agriculture [ 1097-0010 ] ; 2020.

RBID : pubmed:32020613

Descripteurs français

KwdFr :
- Animaux (MeSH), Cellules cultivées (MeSH), Cytokines (métabolisme), Digestion (MeSH), Facteur de transcription NF-kappa B (métabolisme), Facteurs immunologiques (métabolisme), Femelle (MeSH), Grains comestibles (composition chimique), Hydrolysats de protéines (pharmacologie), Lymphocytes T (effets des médicaments et des substances chimiques), Lymphocytes T (métabolisme), Macrophages (effets des médicaments et des substances chimiques), Macrophages (métabolisme), Mitogen-Activated Protein Kinases (métabolisme), Mâle (MeSH), Protéines végétales (composition chimique), Rat Wistar (MeSH), Rate (effets des médicaments et des substances chimiques), Rate (métabolisme), Récepteurs de type Toll (métabolisme), Souris de lignée C57BL (MeSH), Souris knockout (MeSH).
MESH :
- composition chimique : Grains comestibles, Protéines végétales.
- effets des médicaments et des substances chimiques : Lymphocytes T, Macrophages, Rate.
- métabolisme : Cytokines, Facteur de transcription NF-kappa B, Facteurs immunologiques, Lymphocytes T, Macrophages, Mitogen-Activated Protein Kinases, Rate, Récepteurs de type Toll.
- pharmacologie : Hydrolysats de protéines.
- Animaux, Cellules cultivées, Digestion, Femelle, Mâle, Rat Wistar, Souris de lignée C57BL, Souris knockout.

English descriptors

KwdEn :
- Animals (MeSH), Cells, Cultured (MeSH), Cytokines (metabolism), Digestion (MeSH), Edible Grain (chemistry), Female (MeSH), Immunologic Factors (metabolism), Macrophages (drug effects), Macrophages (metabolism), Male (MeSH), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), Mitogen-Activated Protein Kinases (metabolism), NF-kappa B (metabolism), Plant Proteins (chemistry), Protein Hydrolysates (pharmacology), Rats, Wistar (MeSH), Spleen (drug effects), Spleen (metabolism), T-Lymphocytes (drug effects), T-Lymphocytes (metabolism), Toll-Like Receptors (metabolism).
MESH :
- chemical , chemistry : Plant Proteins.
- chemical , metabolism : Cytokines, Immunologic Factors, Mitogen-Activated Protein Kinases, NF-kappa B, Toll-Like Receptors.
- chemistry : Edible Grain.
- drug effects : Macrophages, Spleen, T-Lymphocytes.
- metabolism : Macrophages, Spleen, T-Lymphocytes.
- chemical , pharmacology : Protein Hydrolysates.
- Animals, Cells, Cultured, Digestion, Female, Male, Mice, Inbred C57BL, Mice, Knockout, Rats, Wistar.

Abstract

BACKGROUND

Brewers' spent grain (BSG) is a relevant, protein-rich by-product of the brewing process. Protein hydrolysates from different sources exert immune-regulatory actions activating toll-like receptors (TLRs), nuclear factor kappa B (NFκB), and mitogen-activated protein kinases (MAPKs). Effects of gastrointestinal digestion have been poorly studied. Here, we studied the immune-regulatory effect of BSG hydrolysates, and their in-vitro-digested products, on rat splenocytes, macrophages, and T lymphocytes RESULTS: In primary cultures of rat spleen cells, BSG hydrolysates induced interleukin 10 and tumor necrosis factor production in basal conditions. Under stimulation with lipopolysaccharide or concanavalin A, hydrolysates further induced interleukin 10 production. Tumor necrosis factor and interferon-γ were inhibited in lipopolysaccharide- and concanavalin-A-stimulated cells respectively. In vitro gastrointestinal digestion attenuated the observed effects. Splenic macrophages and T lymphocytes behaved in a similar fashion. In spleen cells from TLR2

CONCLUSION

BSG hydrolysates, like those obtained from other food sources, regulate the immune response, involving TLR2 and TLR4 and the activation of NFκB and MAPKs, an effect partly maintained after in vitro gastrointestinal digestion. Our data support the hypothesis of a shared, rather unspecific, mechanism of action of protein hydrolysates. © 2020 Society of Chemical Industry.

DOI: 10.1002/jsfa.10313
PubMed: 32020613

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Cytokines (metabolism)</term>
<term>Digestion (MeSH)</term>
<term>Edible Grain (chemistry)</term>
<term>Female (MeSH)</term>
<term>Immunologic Factors (metabolism)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (metabolism)</term>
<term>Male (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mice, Knockout (MeSH)</term>
<term>Mitogen-Activated Protein Kinases (metabolism)</term>
<term>NF-kappa B (metabolism)</term>
<term>Plant Proteins (chemistry)</term>
<term>Protein Hydrolysates (pharmacology)</term>
<term>Rats, Wistar (MeSH)</term>
<term>Spleen (drug effects)</term>
<term>Spleen (metabolism)</term>
<term>T-Lymphocytes (drug effects)</term>
<term>T-Lymphocytes (metabolism)</term>
<term>Toll-Like Receptors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cytokines (métabolisme)</term>
<term>Digestion (MeSH)</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Facteurs immunologiques (métabolisme)</term>
<term>Femelle (MeSH)</term>
<term>Grains comestibles (composition chimique)</term>
<term>Hydrolysats de protéines (pharmacologie)</term>
<term>Lymphocytes T (effets des médicaments et des substances chimiques)</term>
<term>Lymphocytes T (métabolisme)</term>
<term>Macrophages (effets des médicaments et des substances chimiques)</term>
<term>Macrophages (métabolisme)</term>
<term>Mitogen-Activated Protein Kinases (métabolisme)</term>
<term>Mâle (MeSH)</term>
<term>Protéines végétales (composition chimique)</term>
<term>Rat Wistar (MeSH)</term>
<term>Rate (effets des médicaments et des substances chimiques)</term>
<term>Rate (métabolisme)</term>
<term>Récepteurs de type Toll (métabolisme)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Souris knockout (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Immunologic Factors</term>
<term>Mitogen-Activated Protein Kinases</term>
<term>NF-kappa B</term>
<term>Toll-Like Receptors</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Edible Grain</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Grains comestibles</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophages</term>
<term>Spleen</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Lymphocytes T</term>
<term>Macrophages</term>
<term>Rate</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term>
<term>Spleen</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Facteurs immunologiques</term>
<term>Lymphocytes T</term>
<term>Macrophages</term>
<term>Mitogen-Activated Protein Kinases</term>
<term>Rate</term>
<term>Récepteurs de type Toll</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Hydrolysats de protéines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Protein Hydrolysates</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Digestion</term>
<term>Female</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Rats, Wistar</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Digestion</term>
<term>Femelle</term>
<term>Mâle</term>
<term>Rat Wistar</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Brewers' spent grain (BSG) is a relevant, protein-rich by-product of the brewing process. Protein hydrolysates from different sources exert immune-regulatory actions activating toll-like receptors (TLRs), nuclear factor kappa B (NFκB), and mitogen-activated protein kinases (MAPKs). Effects of gastrointestinal digestion have been poorly studied. Here, we studied the immune-regulatory effect of BSG hydrolysates, and their in-vitro-digested products, on rat splenocytes, macrophages, and T lymphocytes RESULTS: In primary cultures of rat spleen cells, BSG hydrolysates induced interleukin 10 and tumor necrosis factor production in basal conditions. Under stimulation with lipopolysaccharide or concanavalin A, hydrolysates further induced interleukin 10 production. Tumor necrosis factor and interferon-γ were inhibited in lipopolysaccharide- and concanavalin-A-stimulated cells respectively. In vitro gastrointestinal digestion attenuated the observed effects. Splenic macrophages and T lymphocytes behaved in a similar fashion. In spleen cells from TLR2</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>BSG hydrolysates, like those obtained from other food sources, regulate the immune response, involving TLR2 and TLR4 and the activation of NFκB and MAPKs, an effect partly maintained after in vitro gastrointestinal digestion. Our data support the hypothesis of a shared, rather unspecific, mechanism of action of protein hydrolysates. © 2020 Society of Chemical Industry.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>11</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>11</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-0010</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>100</Volume>
<Issue>7</Issue>
<PubDate><Year>2020</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Journal of the science of food and agriculture</Title>
<ISOAbbreviation>J Sci Food Agric</ISOAbbreviation>
</Journal>
<ArticleTitle>Molecular action mechanism of anti-inflammatory hydrolysates obtained from brewers' spent grain.</ArticleTitle>
<Pagination><MedlinePgn>2880-2888</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/jsfa.10313</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Brewers' spent grain (BSG) is a relevant, protein-rich by-product of the brewing process. Protein hydrolysates from different sources exert immune-regulatory actions activating toll-like receptors (TLRs), nuclear factor kappa B (NFκB), and mitogen-activated protein kinases (MAPKs). Effects of gastrointestinal digestion have been poorly studied. Here, we studied the immune-regulatory effect of BSG hydrolysates, and their in-vitro-digested products, on rat splenocytes, macrophages, and T lymphocytes RESULTS: In primary cultures of rat spleen cells, BSG hydrolysates induced interleukin 10 and tumor necrosis factor production in basal conditions. Under stimulation with lipopolysaccharide or concanavalin A, hydrolysates further induced interleukin 10 production. Tumor necrosis factor and interferon-γ were inhibited in lipopolysaccharide- and concanavalin-A-stimulated cells respectively. In vitro gastrointestinal digestion attenuated the observed effects. Splenic macrophages and T lymphocytes behaved in a similar fashion. In spleen cells from TLR2<sup>-/-</sup>
 and TLR4<sup>-/-</sup>
 mice, immune-regulatory effects were greatly reduced or abrogated. The study of signal transduction pathways indicated a major involvement of NFκB, and the contribution of MAPKs p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinases 1 and 2.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">BSG hydrolysates, like those obtained from other food sources, regulate the immune response, involving TLR2 and TLR4 and the activation of NFκB and MAPKs, an effect partly maintained after in vitro gastrointestinal digestion. Our data support the hypothesis of a shared, rather unspecific, mechanism of action of protein hydrolysates. © 2020 Society of Chemical Industry.</AbstractText>
<CopyrightInformation>© 2020 Society of Chemical Industry.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cian</LastName>
<ForeName>Raúl E</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>Instituto de Tecnología de Alimentos, CONICET, FIQ - UNL, Santa Fe, Argentina.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hernández-Chirlaque</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology II, CIBERehd, School of Pharmacy, Instituto de Investigación, Biosanitaria (ibs.GRANADA), University of Granada, Granada, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gámez-Belmonte</LastName>
<ForeName>Reyes</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, CIBERehd, School of Pharmacy, Instituto de Investigación Biosanitaria (ibs.GRANADA), University of Granada, Granada, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drago</LastName>
<ForeName>Silvina R</ForeName>
<Initials>SR</Initials>
<AffiliationInfo><Affiliation>Instituto de Tecnología de Alimentos, CONICET, FIQ - UNL, Santa Fe, Argentina.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sánchez de Medina</LastName>
<ForeName>Fermín</ForeName>
<Initials>F</Initials>
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<Country></Country>
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<Country></Country>
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<Grant><Agency>Ministerio de Educacion, Spain</Agency>
<Country></Country>
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<Grant><GrantID>Plan Propio</GrantID>
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<MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName>
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<Keyword MajorTopicYN="N">TLR4</Keyword>
<Keyword MajorTopicYN="N">brewing process by-product</Keyword>
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<Month>12</Month>
<Day>17</Day>
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<ReferenceList><Title>REFERENCES</Title>
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</ReferenceList>
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<tree><country name="Argentine"><noRegion><name sortKey="Cian, Raul E" sort="Cian, Raul E" uniqKey="Cian R" first="Raúl E" last="Cian">Raúl E. Cian</name>
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<name sortKey="Drago, Silvina R" sort="Drago, Silvina R" uniqKey="Drago S" first="Silvina R" last="Drago">Silvina R. Drago</name>
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<country name="Espagne"><region name="Andalousie"><name sortKey="Hernandez Chirlaque, Cristina" sort="Hernandez Chirlaque, Cristina" uniqKey="Hernandez Chirlaque C" first="Cristina" last="Hernández-Chirlaque">Cristina Hernández-Chirlaque</name>
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<name sortKey="Sanchez De Medina, Fermin" sort="Sanchez De Medina, Fermin" uniqKey="Sanchez De Medina F" first="Fermín" last="Sánchez De Medina">Fermín Sánchez De Medina</name>
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Molecular action mechanism of anti-inflammatory hydrolysates obtained from brewers' spent grain.

Molecular action mechanism of anti-inflammatory hydrolysates obtained from brewers' spent grain.

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